The National Center for Computational Sciences (NCCS) hosts a global community of users solving some of the world’s largest scientific challenges, and a secure computing environment is critical to their successful research. Users and industry partners are supported by a cybersecurity team that monitors systems 24/7 and administers data management platforms to ensure compliance in regard to security, operations, and the laboratory as a whole. In 2021, the NCCS introduced CITADEL, a framework of security protocols that allows researchers to use supercomputing for projects that involve protected data. This unprecedented framework – the result of a collaboration among the High-Performance Computing (HPC) Cybersecurity and Information Engineering group, the HPC Scalable Systems group, the Scalable Protected Data Facilities in the NCCS, and Oak Ridge National Laboratory’s (ORNL’s) Information Technology Services Division – directly supports projects from the US Department of Veterans Affairs and the National Institutes of Health, which use sensitive personal data for critical health research.